Cyprotex phototoxicity
WebCyprotex Feb 2024 - Present3 years 3 months Watertown, Massachusetts Lab Research with focus on toxicology Performed experiments using the AMES test, phototoxicity … WebEstablished in 1999, Cyprotex Limited was acquired by Evotec (www.evotec.com) in 2016. Cyprotex, an Evotec company, has sites at Alderley Park near Macclesfield, UK and in Framingham near Boston, USA. The company has dedicated and highly qualified employees with proven experience in a wide range of specialist techniques acquired across diverse …
Cyprotex phototoxicity
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WebPhotobiological reactions normally occur when a chemical is able to absorb UV or visible light. Four different endpoints of concern should be specifically addressed in photosafety testing: • Phototoxicity (photoirritation), which is an acute light-induced skin response to a photoreactive chemical. Web70 • Phototoxicity (photoirritation): An acute light- induced tissue response to a photoreactive ch emical. 71 • Photoallergy: An immunologically mediated reaction to a chemical, initiated by the formation of 72 photoproducts (e.g., protein adducts) following a photochemical reaction. 73 Photosensitization is a general term occasionally ...
WebThe dermal phototoxicity of a chemical is defined as a toxic response that is elicited after exposure of skin to the chemical or systemic administration of the chemical, and subsequent exposure to light. As demonstrated in several validation studies (1Œ3), the phototoxic potential of chemicals can be effec-tively assessed by in vitro methods ... WebThree in vitro tests for phototoxicity: the destruction of histidine, killing of mouse peritoneal macrophages and inhibition of PHA-stimulated DNA synthesis in human lymphocytes have demonstrated this photosensitizing potential with UVA irradiation at an order of magnitude lower than that for nalidixic acid. The Candida albicans test and ...
WebAug 20, 2010 · Dr Anthony Baxter, Cyprotex’s Chief Executive Officer, comments on the launch of the new toxicology facility. “Drug toxicity, and drug-induced liver injury in … WebFounded in 1999, Cyprotex (www.cyprotex.com) has grown to become an industry leader in in vitro and in silico ADME-Tox. The company, with sites in the UK and USA, was acquired by Evotec...
WebThis gives Cyprotex's Macclesfield site the same in vitro toxicology capabilities as those of Apredica (Watertown, MA, USA), which Cyprotex acquired on 6 August 2010. ... hERG inhibition; - toxicological gene regulation; - phospholipidosis; - phototoxicity; - haemolysis; - genotoxicity; and - a full spectrum of drug-drug interaction assays.
WebDec 1, 2024 · Of the 1134 cases of phototoxicity, 427 (37.7%) were mild phototoxic reactions requiring no medical treatment; 114 (10.1%) required medical interventions, such as discontinuation of medication, switching of medication, or treatment with oral corticosteroids or antihistamines. The severity of the reaction was not reported in the … bishopswood golf club tadleyWebCyprotex's phototoxicity assays are based upon a comparison of the cytotoxicity of a test compound when tested with and without additional exposure to a non-toxic … bishops wood hospital bmiCyprotex’s phototoxicity service is a non-GLP screening assay performed using Balb/c 3T3 cells. The cells are incubated with increasing concentrations of the test article in the presence and absence of a non-toxic dose of UVA irradiation. Cytotoxicity is assessed via Neutral Red uptake. bishops wood hospital appointmentsWebThe photocytotoxicity depends on the many factors, such as the intrinsic photochemical properties of the photosensitizer (quantum yield and lifetime of the triplet state), … bishops wood hospital - northwoodWebAug 20, 2010 · Dr Anthony Baxter, Cyprotex's Chief Executive Officer, comments on the launch of the new toxicology facility. "Drug toxicity, and drug-induced liver injury in particular, is a major reason for... bishops wood hospital parkingWebJan 25, 2024 · Due to its non-immunological nature, phototoxicity can only occur in skin areas receiving light . Delineation of clothing and its shading capacity is an important clinical feature when making a diagnosis . Mechanisms of phototoxic skin damage. There are several pathways that ultimately lead to the observed phototoxic skin response, but ... dark souls lightning spear opWebJul 5, 2024 · Cyproterone (sye pro' ter one) is a synthetic steroidal antiandrogen that has been used to treat prostate cancer in many countries of the world, but was never approved for this use in the United States. … bishops wood hospital radiology