WebKeywords---Hepatotoxicity, L-carnitine, Cytarabine, Liver enzyme, Antioxidants. Introduction The liver serves many metabolic functions. It has enormous regenerative capacity. WebChemotherapy hepatotoxicity and dose modification in patients with liver disease: Conventional cytotoxic agents …contemporary reports, cytarabine infrequently causes histologically proven cholestasis . Furthermore, transiently abnormal LFTs developed in 24 of 27 patients undergoing high-dose cytarabine by 72-hour continuous …
Cytarabine - StatPearls - NCBI Bookshelf
WebDec 2, 2016 · Cytarabine (Ara C) is considered the most effective chemotherapeutic agent in acute myeloid leukemia (AML) treatment. Several studies suggest that single nucleotide polymorphisms (SNPs) within the genes involving metabolic pathway of Ara C could influence in treatment outcomes, although their clinical relevance remains undetermined. … WebCytarabine (1b-arabinofuranosylcytosine, cytosine arabinoside or ara-C) ... In another dog with grade III hepatotoxicity, ultrasonography and liver aspirates revealed neither vacuolar hepatopathy nor lymphoma, so this was attributed to cytarabine toxicity. Grade I and II elevations were seen in two further dogs but no further investigations ... graphic combat
Cytarabine - UpToDate
WebJun 1, 2024 · The most common adverse effects of cytarabine include myelosuppression, nausea, vomiting, diarrhea, and immune-suppression related infection. 5, 9 There is minimal published literature to establish a definitive link between cytarabine and hepatotoxicity. This is further complicated by the varying dosages of HiDAC. WebMay 9, 2024 · A general discussion of the clinical presentation, pathogenesis, diagnosis, differential diagnosis, and management of antineoplastic agent-induced pulmonary toxicity is covered elsewhere, as is lung toxicity associated with molecularly targeted agents. WebJun 1, 2024 · This is further complicated by the varying dosages of HiDAC. As a case in point, our patient suffered severe hepatotoxicity at an empirically reduced dose for her … graphic columns