Dranoff g. nature reviews cancer 2004
WebMar 24, 2024 · Insights into the effects of targeted therapies, conventional chemotherapy and radiation therapy, on the induction of antitumour immunity will help to advance the design of combination strategies ... WebBlocking antibodies to the immune checkpoint receptors or their ligands have revolutionized the treatment of diverse malignancies. Many tumors are recognized by adaptive …
Dranoff g. nature reviews cancer 2004
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WebMay 9, 2024 · From the reviews: “This book comprises 13 reviews, contributed by members of a cross-section of groups working in the … field of cancer immunology. … this book is at its best when considering small and apparently discrete topics – its strength comes from being able to read all of these ideas on one place. … WebDec 2, 2011 · This review addresses the major challenges related to the translation of cancer nano-based vaccines to the clinic, discussing the requirements for ex vivo and in vivo models of cancer to ensure ...
WebAug 23, 2006 · Interleukin-6 (IL-6) is a pleiotropic cytokine with obviously tumor-promoting and tumor-inhibitory effects. Here, we review the role of IL-6 in in vitro experiments of breast tumor cells, in breast tumor tissues (BTs) and assess its potential as a prognostic indicator in breast cancer patients. A literature search was conducted using PubMed ... WebJan 12, 2024 · To curate the signature genes of cytotoxic lymphocytes (CLs) and explore the heterogeneity based on the CL-related (CLR) gene signature, we analyzed the gene expression of 592 patients with histologically diagnosed triple-negative breast cancer. Based on the 13-gene panel, CLR signatures were curated and associated with the …
WebTumors exploit these coinhibitory pathways to evade immune eradication. Blockade of the PD-1 and CTLA-4 checkpoints is proving to be an effective and durable cancer immunotherapy in a subset of patients with a variety of tumor types, and additional combinations are further improving response rates. In this review we discuss the … WebDec 21, 2011 · This Review summarizes recent work on vaccines, T-cell immunomodulators and other active immunostimulants that, together with targeted therapies, could lead to cancer therapies in years to come.
WebDec 1, 2005 · In this issue of Clinical Cancer Research, Wolf and colleagues present compelling evidence that underscores a key role for regulatory T cell–induced immune suppression in tumor pathogenesis (1). Although most cancer patients mount innate and adaptive antitumor reactions, the evolution of clinically evident disease implies a failure …
WebVanneman, M., & Dranoff, G. (2012). Combining immunotherapy and targeted therapies in cancer treatment. Nature Reviews Cancer, 12(4), 237–251. doi:10.1038/nrc3237 kenny the jet smith arrestedWebApr 9, 2015 · Although cancer immunotherapy can lead to durable outcomes, the percentage of patients who respond to this disruptive approach remains modest to date. Encouragingly, nanotechnology can enhance the efficacy of immunostimulatory small molecules and biologics by altering their co-localization, biodistribution, and release … kenny the pirate disneyWebDranoff G. Cytokines in cancer pathogenesis and cancer therapy. Nature reviews Cancer. 2004;4:11-22 30. Lakshmi Narendra B, Eshvendar Reddy K, Shantikumar S, Ramakrishna S. Immune system: a double-edged sword in cancer. Inflammation research: official journal of the European Histamine Research Society [et al]. 2013; ... kenny the king cigars