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WebIntroduction. The deposition of amyloid-β proteins (Aβ) in the brain (specifically, 40 amino acid peptide Aβ 1–40 and 42 amino acid peptide Aβ 1–42) is a major hallmark of Alzheimer’s disease (AD). 1 Both Aβs impair neurological function; however, the Aβ 1–42 peptide aggregates more readily and is more neurotoxic than Aβ 1–40.Furthermore, … WebFeb 25, 2006 · Whole-cell patch clamp recording was used to investigate the action of beta-amyloid peptide(1-40) (Abeta(1-40)) on high voltage-activated calcium channel current (I(HVA)) in acutely isolated hippocampal CA1 pyramidal neurons in rats and observe its modulation by ginkgolide B (GB). Drug was applied b …
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