Nettet15. feb. 2024 · JP2, Tnni3, and Mybpc3 are the substrates catalyzed by Calpain/CAPNS1 in the hearts. Mutations of Jp2, Tnni3, and Mybpc3 are closely relevant to the heart … NettetRecently, calpain-2 (CAPN2) was reported to cleave JP2 at a novel site between Glycine 482 (G482) and Threonine 483 (T483). We aimed to directly compare the contributions …
Molecular Determinants of Calpain-dependent Cleavage of …
NettetJunctophilin-2 (JP2), a membrane-binding protein that provides a structural bridge between the plasmalemma and sarcoplasmic reticulum (SR), is essential for precise Ca2+ … Nettet1. feb. 2024 · No evidence was found for proteolysis of dihydropyridine receptor (DHPR), junctophilin (JP)1, JP2, ryanodine receptor (RyR), sarcoplasmic reticulum Ca 2+ … scully 03111
In vitro calpain cleavage reactions identify calpain as the JP2 ...
Nettet1. aug. 2024 · Calpain is hyperactivated in human failing hearts and rodent heart failure models of different etiologies. • Inhibition of calpain activity with MDL-28170 protects … Nettet21. des. 2024 · Junctophilin-2 (JP2) is a structural protein required for normal excitation-contraction (E-C) coupling. After cardiac stress, JP2 is cleaved by the calcium ion … Nettet15. okt. 2024 · Calpain proteolysis contributes to the pathogenesis of heart failure but the calpain isoforms responsible and their substrate specificities have not been rigorously … scully 01445